RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
mir-200a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
qRT-PCR; etc.
Target
NA
Pathway
NA
PubMed ID
Title
Participation of miR-200 in pulmonary fibrosis
Year
2012
Function
"MiR-200a, miR-200b, and miR-200c are significantly down-regulated in the lungs of mice with experimental lung fibrosis. Levels of miR-200a and miR-200c were reduced in the lungs of patients with IPF miR-200 had greater expression in AECs than in lung fibroblasts, and AECs from mice with experimental pulmonary fibrosis had diminished expression of miR-200. The miR-200 family members inhibit transforming growth factor-B1-induced epithelial-mesenchymal transition of AECs, reverse the fibrogenic activity of pulmonary fibroblasts from mice with experimental pulmonary fibrosis and from patients with IPF. The introduction of miR-200c diminishes experimental pulmonary fibrosis in mice."